Enantiomers – Image | Mirror Image

Enantiomers – Image | Mirror Image

Chirality has a huge impact on the chemistry of a molecule. Due to potentially different physiological effects, pharmaceutical compounds are often used as enantiomerically pure compounds. One enantiomer can act as a healing agent, the other might be toxic to humans. Crazy, right? It makes sense, if you think of how pharmaceuticals work in principle. They bind to receptors, which trigger something in the brain or somewhere else in the human body. These receptors have a special chemical specificity and only the active compounds fit and bind correctly with it. A receptor is a 3D body and thereby is dependent on the stereochemistry of the compounds.

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Eat Your Heart Out Mass Spec: Measuring 10B/11B Isotopic Ratio by NMR Spectroscopy

Eat Your Heart Out Mass Spec: Measuring 10B/11B Isotopic Ratio by NMR Spectroscopy

As I’m sure the readers of this blog know, NMR spectroscopy is used widely across all branches of chemistry due to its powerful structure elucidation capabilities and the inherently quantitative nature of the technique.  Organic relies primarily on 1H/13C  experiments where as inorganic chemistry can expand to other nuclei, like 31P and 11B.  However, there are many other applications for NMR other than just structural elucidation.  Perhaps a lesser known application of NMR spectroscopy, is its ability to determine the isotopic ratio of elements! In this blog post I would like to demonstrate a novel method to determine the 10B/11B isotopic ratio using our NMReady-60e and 1H NMR spectra! 

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2017 Year in Review

2017 Year in Review

With great advances in areas such as metabolomics, quantitative NMR, and online analysis, 2017 was a very exciting year for NMR in general, but specifically so for Benchtop NMR! Benchtop NMR has continued to make NMR, one of the strongest characterization techniques, become a mainstream staple in teaching and research laboratories. As users realize how easy it is to incorporate the NMReady-60 spectrometers into their laboratories, they have continued to breakthrough into new and exciting applications.

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To D2O or not to D2O?

To D2O or not to D2O?

In the average case one can simply dissolve an analyte in an appropriate deuterated solvent and acquire a simple 1D spectrum to obtain all the required structural information.  However, sometimes doing so may not provide you with all of the information you need!  It is not uncommon to encounter labile proton peaks in functional groups such as alcohols, amines, amides, and carboxylic acids. 

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'Hop' off the Diagonal: COSY spectrum of α-humulene

'Hop' off the Diagonal: COSY spectrum of α-humulene

NMR spectroscopy is by far the most useful characterization technique in organic chemistry, especially if you have to elucidate the structure or configuration of your products. Arguably, 2D experiments such as COSY, HSQC, and HMBC have simplified this task tremendously. In this post I wanted to highlight the COSY of α-humulene. 

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Life is sweet…maybe too sweet!

Life is sweet…maybe too sweet!

Sugar substitutes are gaining more and more relevance due to the heath problems associated with the consumption of high amounts of sugar. Specifically, excess sugar consumption has been associated with obesity, type II diabetes, cardiovascular disease, certain cancers, and tooth decay. In the United States, it is estimated that the average person consumes more than 126 grams of sugar per day, in Canada around 89 grams per day.

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