Beyond structural elucidation, introduction to qNMR – Part I

Beyond structural elucidation, introduction to qNMR – Part I

Over the last few years, more and more analytical and industrial laboratories have started employing quantitative nuclear magnetic resonance (qNMR) spectroscopy as a tool for content assignment (due to its superb structural elucidation abilities) and quantification of purity in a sample. This is due to the increase in regulations being imposed by governments onto the pharmaceutical and environmental sectors. It has been previously demonstrated that qNMR spectroscopy can give results with less than 1% uncertainty and possibly down to 0.1% if the right conditions are met.

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Lead NMR Spectroscopy

Lead NMR Spectroscopy

For many years tetraethyl lead was used as the principal fuel additive to enhance the octane rating of gasoline. In the mid-1970s the use of this substance was reduced because of the environmental hazards of lead and because it poisons catalytic converters. Nowadays, the main application of lead metal and lead oxide is in lead-acid batteries. In this application the cathode of the cell consists of lead dioxide packed on a metal grid and the anode is composed of lead metal. The electrochemical reaction is shown in the following equation:

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Boron NMR Spectroscopy

Boron NMR Spectroscopy

For my first blog I have decided to talk a little bit about boron because it’s a fascinating element that imparts remarkable properties to its compounds. And believe me, there are hundred of different compounds with very different properties containing boron centers. We find boron in compounds like boronic acids (A), boronic esters (B), and MIDA boronates (C), all of which are very popular in Suzuki coupling reactions to make new C–C bonds.  Another popular family of compounds containing boron are the BODIPY dyes (D). These derivatives, composed of a dipyrromethene ligand supporting a BF2 unit, are used as stable functional dyes in several fields, but their application as biomolecular labels is the most investigated by far.

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