Nucleophilic Substitution Reactions and Benchtop NMR

Nucleophilic Substitution Reactions and Benchtop NMR

Nucleophilic substitution reactions are frequently performed as an experiment in undergraduate organic chemistry courses. Reactions taking place at saturated carbons are mainly classified as SN1 or SN2, where S stands for substitution, N for nucleophilic, and the number indicates the molecularity of the reaction (1 for a unimolecular process, 2 for a bimolecular process). In the SN2 reaction the attack of the nucleophile and elimination of the leaving group occur simultaneously in a concerted process and its rate is proportional to the concentration of both the alkyl halide and the nucleophile.

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Follow the Circuitry Road Part II: The little proton signal that could

Follow the Circuitry Road Part II: The little proton signal that could

Welcome back!  If you recall from our last blog, we followed a bench-top NMR electronics blueprint to highlight the technology that allows the generation of an excitation wave and tailors it to nutate our hydrogen nuclei in our sample.  Now, keeping with our goal of demystifying the technology of ...

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