NMR Spectroscopy is the most commonly used analytical technique in the chemists’ toolbox. This information-rich tool allows a user to elucidate molecular structure by providing evidence of the type, number, and connectivity of the constituents composing a molecule.
For traditional superconducting spectrometers, access to this technique is typically limited to a central NMR facility. With the addition of the NMReady benchtop NMR spectrometer, you can now have an additional layer of NMR workflow. While the benchtop NMR is not meant to replace a high-field NMR spectrometer fully, there a number of applications where benchtop NMR can be used to improve your daily productivity, streamline your process, and reduce your costs.
Why would you use benchtop NMR?
1) You need quantitative data. Fast.
NMR Spectroscopy is an inherently quantitative, linear technique. This means that the relative integrations of resonances can be used determine relative or absolute molar ratios of the components in solution. It can be a quick, easy and precise alternative to chromatographic methods that typically consume large quantities of solvent and require long run times.
2) Your high-field NMR spectrometer is always busy.
You need to see if a reaction has finished, or if a reagent or product is clean, but there is no available time on your high-field NMR spectrometer. The NMReady can easily be used for these applications, and you can save queuing on the high-field for full structural elucidation of new molecules.
3) You're spending a fortune on outsourcing analytical costs.
The NMReady is an affordable capital cost with no additional maintenance charges. It uses 5mm NMR tubes so you can easily make up samples, pre-screen them on the benchtop and outsource only samples that require additional characterization and/or better resolution.
4) You need relaxation AND speciation data.
Relaxometers are useful to determine bulk properties of solutions (e.g., solid fat content (SFC), moisture content, viscosity, etc.), but in addition to these measurements you would like to know about the chemical composition as well (e.g., saturated vs. unsaturated fatty acid compositions). NMReady resolves both needs.
5) NMR has been recommended to you for routine analysis, but you're not an expert.
The NMReady can be easily configured into an ‘analyzer’ type mode from our application programmatic interface (NMReady-CONNECT) where users can acquire data without needing to understand or interpret the data they’re looking at. This can be done quantitatively or qualitatively. Please inquire if you’d like more information.
6) You want to introduce a hands-on component to your students.
Anyone who’s taught NMR Spectroscopy to undergraduates know that it is initially one of the hardest techniques to understand. The inability of students to access traditional NMR spectrometers, which are typically allocated to more advanced researchers, make this technique even more mystifying. The ability to let the students make and run their samples, as early as their freshman year, can immeasurably aid students in their handle on the theory and application of this vital analytical tool.
7) Your application would benefit from NMR Spectroscopy, but for logistical reasons, superconducting magnets are not feasible.
Capital cost, operating expenditures, size and infrastructure are the typical limiting factors in the choice of a superconducting NMR system and preclude its use in your application. For example, you want to monitor a process in the lab, in a glovebox or even on a process line using NMR Spectroscopy.
8) You really like NMR. Like Really. Really.
And have secretly dreamed of having one on your desk to play with, design pulse sequences on, solve second order multiplicites with, etc....