How Can NMR Be Used For Reaction Monitoring?

nmr spectrometer

Creating new drugs isn't cheap. In fact, it can be outrageously expensive. That's why reducing costs in all parts of the drug discovery and delivery road map is a top priority in the pharmaceutical and chemical industry.

When chemists know what's happening in real-time, they can control the reactions in the process vessels. This increases product purity and yields and reduces side-reactions and by-products. That's where reaction monitoring comes in.

What is reaction monitoring?

Reaction monitoring is a process that's used during the research manufacturing phases of drug discovery and delivery. It helps chemists deliver reliable, cost-efficient, and safe processes.

Reaction monitoring can be used to optimize process conditions - including temperature, duration, pH, etc.  Once optimized, chemically specific monitoring can also be used to make sure that the reaction is progressing as as chemists expected. To monitor reactions, there are many instrumental techniques. While Infrared (IR) spectroscopy is one of the most common, it is limited by: 1) turbid solutions; 2) the need for extensive calibration; and 3) inability to discriminate between structural isomers.  This is why NMR is favourable.  

How can NMR be used as an instrumental technique?

NMR Spectroscopy is the technique of choice for most organic synthesis, because it provides researchers with evidence of molecular structure in a qualitative and quantitative manner. 

NMR is used to identify organic compounds quickly and reliably so chemists can determine what has been made at each stage of the reaction monitoring process. This includes any unexpected by-products that may impact the drug discovery road map.

Recent technological advances have enabled benchtop NMR spectrometers to be developed, and any NMReady-60e or 60PRO can convert into an online detector for in-lab reaction monitoring. This is beneficial for lab-based organic chemists.

Chemists can use an NMReady-flow accessory and recommended liquid handling system to automate repeated syntheses, improve reaction safety and yield, integrate the NMReady a centralized control system, and automatically or manually optimize and understand chemical reactions in real-time.

Where can I find a benchtop NMR spectrometer for my lab?

It's no secret that modern chemistry has a major role to play in many different industries and applications. In fact, drug discovery is a multi-billion dollar industry and chemists play an integral role in many points on the industry road map.

Benchtop NMR spectrometers make it possible to use NMR spectroscopy and NMR interpretation software in the comfort of your own chemistry lab for reaction monitoring. For more information about tabletop NMR spectrometers and how they can be used for reaction monitoring, contact Nanalysis today.