In the pharmaceutical industry, an important consideration to make before sending a drug into market is determining its shelf life. To determine a drug’s shelf life, it often goes through stress testing which involves exposing a drug to various environments to observe potential degradation. With the information gained from these experiments, scientists can predict how a drug will behave under normal storage conditions. In addition, scientists can uncover the mechanisms on how a drug degrades which allows them to set a drug’s expiration date and optimal conditions for storage.
To monitor the degradation of drugs, NMR is a useful method in determining degradation products without the need of physical separation.1 To illustrate this, an acidic stress test of the drug, voriconazole, was conducted via 1H NMR. Voriconazole was selected as the candidate of study because it is a fluorinated drug, thus it opens an avenue for further discovery into analyzing degradation pathways via 19F (Figure 1). Additionally, since Barbosa et al. previously conducted similar studies using high-field instrumentation, it was of interest to determine whether the results reported in the literature were consistent with results obtained using our benchtop spectrometer.