In Situ Chemistry: Introducing Our New Nanalysis-100 Flow Cell

The landscape of chemical process monitoring has been transformed by Process Analytical Technology (PAT), which represents a paradigm shift from traditional batch-to-batch to real-time process understanding and optimization. PAT is an extremely powerful and useful tool for analyzing, optimizing and controlling chemical processes, particularly benefiting chemical, food and pharmaceutical industries. Unlike conventional approaches that rely solely on physical parameters like temperature and pH, modern PAT integrates spectroscopic techniques to provide crucial chemical information about reactions as they occur. NMR spectroscopy stands out as uniquely suited for PAT applications because it is independent of sample matrix, requires no calibration, and delivers data quickly and frequently.1 This real-time monitoring capability enables manufacturers to prevent costly batch failures, reduce environmental impact, and ensure consistent product quality while gaining deeper insights into their chemical processes.

We are excited to announce the release of our flow cell accessory for the Nanalysis-100, the highest field strength benchtop NMR available in the market today. The flow cell brings unique analytical capabilities directly to your laboratory or production environment, enabling continuous online reaction monitoring with superior signal dispersion and enhanced sensitivity that only our 100 MHz platform can deliver. The higher magnetic field strength provides exceptional spectral resolution, allowing you to distinguish between closely related compounds and monitor complex reaction pathways with confidence. Combined with a variety of software solutions, like the application programmatic interface (API), Remote Access and Experiment Designer, the flow cell enables custom automation and easy data management workflows.

Figure 1. Stack plot of a Wittig reaction monitored using the Nanalysis-100 flow cell

 

The introduction of our 100 MHz flow cell represents a significant milestone in making advanced NMR technology accessible for routine process monitoring. By combining the highest field strength available in benchtop NMR with sophisticated flow cell technology and smart software integration, we are empowering chemists and process engineers to make data-driven decisions in real-time, leading to more efficient processes and accelerated development timelines. Together with our established auto sampler capabilities, this flow cell represents a complete analytical ecosystem designed to meet the demanding requirements of modern process chemistry and pharmaceutical development. If you want to learn more, get in touch with us!

Figure 2. Nanalysis-100 in flow mode

 
Next
Next

Your Nanalysis-60 Order!