2D NMR Experiments - HETCOR

2D NMR Experiments -  HETCOR

2D NMR experiments can provide an abundance of information for the structural elucidation of chemical compounds. An older example of a 2D experiment is the heteronuclear correlation (HETCOR) sequence. In this experiment, two different nuclei (usually 13C and1H) are correlated through single bond spin-spin coupling, revealing which proton and carbon groups are bonded to each other.

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Getting COSY with the TOCSY Experiment

Getting COSY with the TOCSY Experiment

2D NMR experiments can provide a wealth of information to aid in the structural elucidation of chemical compounds. Of the many 2D NMR experiments available, the homonuclear correlation spectroscopy (COSY) sequence is one of the most popular and is used to identify which spin systems are directly coupled to each other. As an example, the 1H-1H COSY spectrum of 1-propanol recorded on the NMReady-60 is shown below in Figure 1.

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HSQC – Revealing the direct-bonded proton-carbon instrument

HSQC – Revealing the direct-bonded proton-carbon instrument

2D NMR experiments provide chemists with evidence to clarify and confirm resonance assignment.  Nowadays every organic chemist uses these experiments called COSY, HMBC and HSQC as routine analytics. Basically, with 2D experiments you correlate some kind of information between two 1D spectra. If we correlate two 1D spectra of the same nucleus we are dealing with homonuclear 2D NMR experiments. The most famous representative of this group is the COSY experiment (find theory here and application here).

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Settle in and get COSY!

Settle in and get COSY!

n November 2014 Nanalysis was pleased to announce the expansion of their product line with the NMReady-60PRO.  With this we also extended our experiment library for the NMReady-60e

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