Reaction Monitoring/Process Analytical Technology (PAT)

Our compact NMR spectrometers facilitates:

• The ability to automatically or manually understand and optimize chemical reactions in real time

• Improve reaction yield and safety

• Automate repeated syntheses

• Track and follow course of chemical intermediates

• Self-optimize reactions

For more information about incorporating benchtop NMR into your daily workflow, please inquire for NMReady-flow accessory or about our PAT hardened products.

100 MH

• Nanalysis-100
- 1H/19F, 1H/19F/13C, 1H/19F/7Li, 1H/19F/31P, etc.

60 MHz

• Nanalysis-60 -1H/19F, 1H/19F/13C, 1H/19F/7Li, 1H/19F/31P, etc.

• The Flow kit allows easy inter-conversion of any Nanalysis-60 and Nanalysis-100 benchtop NMR spectrometer into an NMR online detector either as a stand-alone tool or in conjunction with other analytical techniques.

  Request a quote for the Nanalysis flow kit.
  

• For a demonstration of how to install an NMR flow kit, and the time required to observe a signal, please watch the Nanalysis-60 Flow setup video or the Nanalysis-100 Flow set up video.

• In Situ Chemistry: Introducing Our New Nanalysis-100 Flow Cell
  

• Real-Time 100 MHz Benchtop NMR Monitoring of the Wittig Reaction: Influence of Aldehyde Activity on Rate and Stereoselectivity
  

• Taking compact NMR to monitoring real reactions in large-scale chemical industries—General considerations and learnings from a lab-scale test case
  

• Exploration of continuous-flow benchtop NMR acquisition parameters and considerations for reaction monitoring
  

• Continuous-flow synthesis and application of polymer-supported BODIPY Photosensitisers for the generation of singlet oxygen; process optimised by in-line NMR spectroscopy
  

• Quantitative and convenient real-time reaction monitoring using stopped-flow benchtop NMR
  

• ‘Continuous-flow synthesis of fluorine-containing fine chemicals with integrated benchtop NMR analysis’ Reaction Chemistry and Engineering (2017)
  

• Process NMR – Developments in Benchtop NMR as Process Analytical Tool (PAT)
  

• Special issue research article (Wiley Online Library) – NMR spectroscopy goes mobile: Using NMR as process analytical technology at the fume hood

If you’re interested in software packages that ease incorporation of your benchtop NMR, please inquire about:

• Installation Qualification/Operational Qualification (IQ/OQ) software modules

• Advanced User interface for optional application programmatic interface to write own pulse programs or control instrument remotely-

• Developments of CFR 21 Part 11 Compliance.

For more information about incorporating benchtop NMR into your daily workflow, please inquire for free sample submission, optional automation, building a database and other tools.