The NMReady family of NMR spectrometers add a new dimension to NMR technology.
Less powerful than a high-field spectrometer, but with more chemical information than a relaxometer, the NMReady allows for more applications of NMR Spectroscopy. Spectroscopy can now be used in markets where it was previously overlooked, and by beginners and experts alike. The compact all-in-one NMReady will fit in virtually any location providing point of need access to NMR. At the bench, in a glovebox, on the manufacturing floor, the loading dock or in the classroom, NMReady provides access to high resolution NMR spectroscopy without the expense, complexity, or ongoing costs of traditional NMR.
There are many useful NMR applications in biotechnology and pharmaceutical industries. 1H and multinuclear NMR Spectroscopy (e.g., 13C, 19F, 31P) are essential tools for structural elucidation and drug discovery. Additionally, they can be used for structural confirmation of both known synthetic drugs and natural products with pharmaceutical effects. See for example, the series of non-steroidal anti-inflammatory drugs (NSAIDs). In addition to qualitative analysis, the quantitative nature of NMR can address a number of inquiries including:(i) impurity profiles;
(ii) composition (e.g., composite β-lactam/β-lactamase inhibitor antibiotics);
(iii) metabolic products in bodily fluids;
(iv) reaction monitoring/kinetic profiling etc..
With a growing number of flow applications developing for benchtop NMR, these analyses can also be done on dynamic samples in dedicated benchtop reactors or larger production facilities.
Related Application Notes:
- Quantification of Composite β-lactam/β-lactamase Antibiotics (2015, 5MB)
- Automatic, High-Throughput Data Processing: Illustrated through NSAIDs (2016, 3MB)
- Amine (R) and (S) Chirality Analyzers: Chemosensors & 19F Benchtop NMR Spectroscopy (2017, 1MB)
Reaction Monitoring/Process Analytical Technology (PAT)
Any NMReady-60e or 60PRO can easily be converted into an online detector for in-lab or process line type reaction monitoring via our flow accessory and recommended liquid handling system. NMReady-flow allows users to:(i) Automatically or manually understand and optimize chemical reactions in real time
(ii) Improve reaction yield and safety
(iii) Automate repeated syntheses
(iv) Integrate the NMReady a centralized control system or Laboratory Information Management System (LIMS)
The robust and compact nature of the NMReady magnet allows you to incorporate a flow system on your bench, fume hood, or process line. If you have any more questions about our PAT hardened products please contact us to learn about recent developments.
Related Application Notes:
- Detection by Online Benchtop NMR Spectroscopy: Hydrogenation Reactions (2017, 600KB)
- 'Continuous-flow synthesis of fluorine-containing fine chemicals with integrated benchtop NMR analysis' Reaction Chemistry & Engineering (March 2017)
- Process NMR - Developments in Benchtop NMR as a Process Analytical Technology (PAT)
Routine, regular polymer characterization is vital to ensure quality and consistency among polymeric products. Polymer analysis by NMR Spectroscopy is an efficacious method to:(i) observe reaction completeness & uniformity;
(ii) qualify the relative composition of the structural components;
(iii) quantify the relative percentage of structural isomers;
(iv) observe the presence of stereoisomers and determine polymeric tacticity; and
(v) determine molecular weight (MW), molecular number (Mn) and polydispersity index (PDI).
Even though polymer NMR analysis has been done on high-field instruments for years, it can be expensive, and, depending on the accessibility and availability of a spectrometer, time consuming. Given that polymer chemistry is not sample limited, and that polymer 1H NMR is often defined by broad, poorly defined peak areas and resolution and peak definition is not a large issue, this is an application ideal for study by either 1H or 19F benchtop NMR.
Related Application Notes:
- Block Co-polymer Characterization (2013, 2MB)
As biodiesel is formed through a simple transesterification, it is easily monitored and characterized by NMR Spectroscopy. This analytical technique allows easy, non-destructive evaluation of many of the components regulated in biodiesel standardization (e.g., water, alcohol, phosphorous, and glycerol content). Subsequently, the NMReady could be easily incorporated into characterization to improve workflow. NMR Spectroscopy can be used to quantify the percentage of biodiesel in composite fuel mixture. Click HERE for a biodiesel spectrum generated on the NMReady and HERE for a related blog entry.
Educational curricula trends are shifting towards hands-on, guided-inquiry approaches that help students obtain meaningful learning. As chemistry laboratories provide the perfect opportunity for students to supplement cognitive learning with psychomotor skills, an increasing number of analytical characterization techniques have been incorporated into procedures (e.g., UV-Vis, IR). Even though applications of NMR spectroscopy in chemistry are the most commonly used characterization technique in inorganic and organic chemistry, it is usually the least available to undergraduate students. As the biggest restriction to including NMR spectroscopy in laboratories is the limited accessibility of high-field NMR, the NMReady provides an easy solution. It is compact, portable and easy-to-use. Moreover, it does not require weekly maintenance and is designed to minimize damage occurred by broken NMR tubes.
Related Teaching Links:
Relaxometry has long been used in food science to determine the solid fat content (SFC), moisture content, etc. Not only can the NMReady perform these fundamental experiments, but, in addition, the option to measure high-resolution 1D 1H NMR acquisition can provide additional invaluable information through speciation (e.g., amount of saturated and unsaturated fats, cis/trans olefin conformations, % carbohydrates). qNMR QA/QC methods are also possible to validate product claims (e.g., carbohydrate content, alcohol percentage, authenticity of the sample or the presence of adulterants).
NMR applications include methods that can be useful in quantifying and speciating dissolved organic matter in earth’s atmosphere, ocean, and soil (e.g., chlorofluorocarbons, benzene, toluene, ethylbenzene & xylene (BTEX), methyl tert-butyl ether (MTBE).
Have questions about the various NMR applications? Please contact us!