In this blog, we showcase how benchtop NMR is an accessible and versatile tool for chemists and non-chemists to evaluate greener methods.

Proton and carbon NMR analyses are routinely used in organic laboratories. In proton, 1H-1H coupling pattern is well exploited, and 1H-13C couplings as referred to as the carbon satellites. However, when acquiring carbon data, proton decoupling is applied most of the time and consequently it is not common to evaluate 1H-13C couplings in routine carbon analysis. This blog discusses the 1H-13C coupling in tert-butanol through 1D and 2D data, highlighting the key info. Read more.

Distortionless Enhancement by Polarization Transfer (DEPT) is a double resonance pulse program that transfers polarization from an excited nucleus to another – most commonly 1H → 13C. This results in a sensitivity enhancement relative to the standard decoupled 1D carbon spectra (13C), which benefits only from the small Nuclear Overhauser Effect (NOE) enhancements.

Tautomers are constitutional isomers that interconvert into each other by an exchange reaction, most commonly a proton transfer. Such two isomers can for example be a ketone and an enol. Keto-enol tautomerism (KET) becomes possible when there are hydrogen atoms adjacent to a carbonyl group (these hydrogen atoms are called α hydrogens). This tautomerism is depicted in Scheme 1 and is also discussed…

Distortionless Enhancement by Polarization Transfer (DEPT) is a double resonance pulse program that transfers polarization from an excited nucleus to another – most commonly 1H → 13C. This results in a sensitivity enhancement relative to the standard decoupled 1D carbon spectra (13C), which benefits only from the small Nuclear Overhauser Effect (NOE) enhancements.

Tautomers are constitutional isomers that interconvert into each other by an exchange reaction, most commonly a proton transfer. Such two isomers can for example be a ketone and an enol. Keto-enol tautomerism (KET) becomes possible when there are hydrogen atoms adjacent to a carbonyl group (these hydrogen atoms are called α hydrogens). This tautomerism is depicted in Scheme 1 and is also discussed…

As Valentine’s Day approaches, I decided to analyze the 1H nuclear magnetic resonance (NMR) spectrum of the main aromatic component of roses, carnations, violets, lilies and chrysanthemums, which were b-damascenone, eugenol, b-ionone, linalool and a-pinene, respectively.

In my opinion, one of the most helpful papers[1] in the field of NMR spectroscopy in Organic Chemistry consists of ‘just’ two tables. In these, the chemical shifts (1H and 13C) of as many as forty-two common impurities in twelve different deuterated solvents are listed. This is gold! Why?

‘The spectra were analyzed according to first order’. Does this sound familiar to you? Most of the supporting information documents out there contain this sentence. You find yourself asking ‘why does nobody care about second order effects?’, then check out this high-order blog entry on the topic.

In my opinion, one of the most helpful papers[1] in the field of NMR spectroscopy in Organic Chemistry consists of ‘just’ two tables. In these, the chemical shifts (1H and 13C) of as many as forty-two common impurities in twelve different deuterated solvents are listed. This is gold! Why?