In this blog, we showcase how benchtop NMR is an accessible and versatile tool for chemists and non-chemists to evaluate greener methods.

Tautomers are constitutional isomers that interconvert into each other by an exchange reaction, most commonly a proton transfer. Such two isomers can for example be a ketone and an enol. Keto-enol tautomerism (KET) becomes possible when there are hydrogen atoms adjacent to a carbonyl group (these hydrogen atoms are called α hydrogens). This tautomerism is depicted in Scheme 1 and is also discussed…

Tautomers are constitutional isomers that interconvert into each other by an exchange reaction, most commonly a proton transfer. Such two isomers can for example be a ketone and an enol. Keto-enol tautomerism (KET) becomes possible when there are hydrogen atoms adjacent to a carbonyl group (these hydrogen atoms are called α hydrogens). This tautomerism is depicted in Scheme 1 and is also discussed…

In this blog post, we show an example for on-line flow reaction monitoring via 19F NMR spectroscopy using the compact benchtop NMR. 1-855-NMREADY (667-3239) toll-free in the US and Canada

Electronegativity is a concept that we have to study and understand early in our science or engineering degrees. In chemistry this concept stays with us and we commonly invoke it in order to explain multiple phenomena what we observe or study…and of course, NMR is not the exception! Benchtop NMR 1-855-NMREADY (667-3239) toll-free in the US and Canada

Tautomers are constitutional isomers that interconvert into each other by an exchange reaction, most commonly a proton transfer. Such two isomers can for example be a ketone and an enol. Keto-enol tautomerism (KET) becomes possible when there are hydrogen atoms adjacent to a carbonyl group (these hydrogen atoms are called α hydrogens). This tautomerism is depicted in Scheme 1 and is also discussed more here.

Due to the presence of unpaired d electrons in their metal ions, many transition metal complexes are paramagnetic. The unpaired electrons have a magnetic dipole moment due to their spin and act like tiny magnets, resulting in a small net attraction to an externally applied magnetic field. Unsurprisingly, the presence of paramagnetic ions has significant effects on both the chemical shift and lineshape of the 1H NMR spectrum of transition metal complexes, with the chemical shift range being much wider along with broadening of the signals.

For this one I must begin with a little personal background information due to my special relationship to the scaffold of the target compound. During my diploma thesis I investigated gold(I) phosphine complexes as catalysts for the intermolecular hydroamidation of olefins.[1] I found that dinuclear gold complex showed superior reaction times and yields compared to mononuclear complexes, like Ph3PAuCl. This particular dinuclear complex [xantphos(AuCl)2] (1) was kicking the reaction of norbornene (2) and tosyl amide (3) and made my first academic publication possible (scheme 1).

Electronegativity is a concept that we have to study and understand early in our science or engineering degrees. In chemistry this concept stays with us and we commonly invoke it in order to explain multiple phenomena what we observe or study…and of course, NMR is not the exception! Benchtop NMR 1-855-NMREADY (667-3239) toll-free in the US and Canada

2,4-pentanedione (aka acetylacetone, acetylacetonato or acacH) is not only a ubiquitous ligand (AND ligand precursor!) for beautifully coloured organometallic complexes[1-3].. Read more.