Beyond Structural Elucidation - Introduction to qNMR Part III - Relaxation Delays

Beyond Structural Elucidation - Introduction to qNMR Part III - Relaxation Delays

In this blog, Part III of the qNMR series, I will be addressing relaxation and why it's important for quantitative nuclear magnetic resonance (qNMR) experiments. If this is your first time reading about qNMR and would like to know more, please check out our other posts where you can find a general introduction to qNMR as well as information for the types of calibrants available for qNMR experiments.

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What's the 'ism' of today? Keto-Enol Tautomerism

What's the 'ism' of today? Keto-Enol Tautomerism

Tautomers are constitutional isomers that interconvert into each other by an exchange reaction, most commonly a proton transfer. Such two isomers can for example be a ketone and an enol. Keto-enol tautomerism (KET) becomes possible when there are hydrogen atoms adjacent to a carbonyl group (these hydrogen atoms are called α hydrogens). This tautomerism is depicted in Scheme 1 and is also discussed more here.

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Beyond Structure Elucidation - Introduction to qNMR Part II - Calibrants

Beyond Structure Elucidation - Introduction to qNMR Part II - Calibrants

In my previous blog post, I introduced several concepts that are relevant to the qNMR experiment. In this blog post, I will talk about how to select a suitable calibrant as well as the difference between using an internal and external calibrant.

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Beyond structural elucidation, introduction to qNMR – Part I

Beyond structural elucidation, introduction to qNMR – Part I

Over the last few years, more and more analytical and industrial laboratories have started employing quantitative nuclear magnetic resonance (qNMR) spectroscopy as a tool for content assignment (due to its superb structural elucidation abilities) and quantification of purity in a sample. This is due to the increase in regulations being imposed by governments onto the pharmaceutical and environmental sectors. It has been previously demonstrated that qNMR spectroscopy can give results with less than 1% uncertainty and possibly down to 0.1% if the right conditions are met.

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How strong was your coffee this morning?

How strong was your coffee this morning?

Who doesn’t want to start the day with a warm cup of coffee? Coffee has a stimulating effect on humans because of its caffeine content and for that reason it has become one of the most popular drinks in the world. Some clinical studies actually suggest that small amounts of caffeine everyday might be beneficial for adults. In this blog I am going to highlight an experiment done in collaboration with the Swager group at MIT using an organometallic complex to quantify the caffeine content in regular coffee without sample preparation!

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Quantitative Analysis

Quantitative Analysis

Owing to the attractive flavour and nutritional characteristics (e.g., it actively lowers LDL cholesterol, aids blood pressure and sugar regulation), olive oil has long been vulnerable to ...

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